As the industry continues to see significant growth for drug products developed using cartridge-based drug delivery systems, there is a trend for pharmaceutical companies to evaluate more complex drug molecules, such as biologics, that require higher injection volume or viscosity.  These biologics are typically intended for self-administration by the patient and integrate into either a prefilled syringe or cartridge as the primary container along with a delivery device to optimize safety, dose accuracy, and ease of use.  The challenge, however, is ensuring the full delivery system (components, container, device) meets the evolving requirements.

Examples will be used to outline key decisions during primary container and device selection and to give an overview of new approaches in the development of next generation technologies for complex injections.  Data will be shared on the key critical product requirements, such as performance, container closure integrity, and fill-finish considerations that can be used to support delivery system assessment and implementation at pharmaceutical companies.  Additional examples will highlight various product and process improvements for cartridge-based drug delivery systems and how the inclusion of new technologies into delivery system selection can impact patient outcomes and mitigate risk during development.



Featured Speakers

Royce C. Brockett

Director, Product Management, Prefilled Systems & Delivery
West Pharmaceutical Services, Inc.

Royce Brockett has 17 years of experience working in the pharmaceutical industry with a focus in sales and marketing. He is currently the Director of Prefilled Systems & Delivery at West Pharmaceutical Services, Inc. His responsibilities include supporting business development efforts, defining new products, and executing marketing strategies including product launches. Royce has published articles related to sterilization techniques for elastomer components, particle reduction strategies, and cartridge technology. Prior to joining West, Royce held various positions within the sales and marketing organization at AbbVie, Solvay, and Pfizer. Royce holds a BS in biochemistry from Lehigh University and an MBA in Health Sector Management from Boston University.

Carl Dabruzzi

Director, Product Management, Self-Injection Systems
West Pharmaceutical Services, Inc.

Carl Dabruzzi has over 20 years of experience in the pharmaceutical and drug delivery industries. He joined West Pharmaceutical Services in 2017 in the Product Management organization. His primary responsibilities involve managing the development and commercialization of West’s portfolio of Self-Injection Systems. The portfolio includes the SmartDose® platform of wearable on-body infusors and the SelfDose™ patient-controlled injection systems. Carl has published articles related to various drug delivery technologies including wearable and handheld injection systems, as well as transdermal and inhalation delivery. Prior to joining West, Carl worked in the Pharmaceutical and Drug Delivery Systems divisions of 3M. He has an extensive background in respiratory and transdermal drug delivery systems that includes biological research, analytical development and validation, regulatory affairs, account and portfolio management, and strategic business development. Carl holds a B.S. in Biochemistry from the University of Wisconsin in River Falls.

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